Baclofen is indicated for the relief of spasticity of voluntary muscle resulting from such disorders as multiple sclerosis, other spinal lesions e.g. tumours of the spinal cord, syringomyelia, motor neurone disease, transverse myelitis, traumatic partial section of the cord. Intrathecal baclofen may be used to treat spasticity in multiple sclerosis, it involves surgically implanting a pump under the skin of the abdomen. Learn more in this A-Z entry. Avoid abrupt discontinuation of intrathecal baclofen therapy. Abrupt discontinuation of intrathecal baclofen, regardless of cause, has resulted in severe reactions including high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, that in rare cases has advanced to rhabdomyolysis, multi-system organ failure, and. Detailed Baclofen dosage information for adults and children. Includes dosages for Spasticity, Cerebral Spasticity and Spinal Spasticity; plus renal, liver and dialysis adjustments. INDICATIONS. LIORESAL INTRATHECAL (baclofen injection) is indicated for use in the management of severe spasticity. Patients should first respond to a screening dose of intrathecal baclofen prior to consideration for long term infusion via an implantable pump. Delivering care. 1.1.1 Children and young people with spasticity should have access to a network of care that uses agreed care pathways supported by effective communication and integrated team working. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for BACLOFEN. CLOFEN – PRODUCT INFORMATION 6 The risk of respiratory depression is also increased. In addition, hypotension has been reported with concomitant use of morphine and intrathecal baclofen. ALERT: U.S. Boxed Warning Abrupt withdrawal (injection): Abrupt discontinuation of intrathecal baclofen, regardless of the cause, has resulted in sequelae that include high fever, altered mental status, exaggerated rebound spasticity, and muscle rigidity, which in rare cases has advanced to rhabdomyolysis, multiple organ-system failure, and death. US Pharm. 2008;33(1):22-26. Cerebral palsy is the leading cause of childhood disability. 1 Current estimates suggest that 764,000 children and adults in the United States have cerebral palsy. 2 The occurrence is 1 to 2.3 cases per 1,000 births. 3 The extent of disability in cerebral palsy can vary from a mild motor disorder to major cognitive.